GDF15 is a dynamic biomarker of the Integrated Stress Response in the central nervous system
Jyoti Asundi, Chunlian Zhang, Diana L. Donnelly‐Roberts, Jose Zavala‐Solorio, Malleswari Challagundla, Caitlin F. Connelly, Christina Boch, Jun Chen, Mario Richter, Mohammad Mehdi Maneshi, Andrew M. Swensen, Lauren LeBon, Raphael Schiffmann, Subhabrata Sanyal, Carmela Sidrauski, , Amos Baruch
This study identifies GDF15 as a biomarker of the Integrated Stress Response in the CNS, showing its correlation with ISR activity in both animal models and human patients.
CNS Neuroscience & Therapeutics · Feb 1, 2024Peer-reviewedNeuroscience