Chunlian Zhang

This study identifies declining Wnt signaling as a driver of age-related alveolar stem cell loss and shows that restoring Wnt signaling in aged mice improves lung repair but not full regeneration.

The paper uses genetic correlation analysis in DO mice to identify QTL and candidate genes linked to age-related pathologies.

This paper shows that an eIF2B activator rescues neonatal lethality in a VWM mouse model but leads to age-related motor deficits and myelin loss.

This study identifies GDF15 as a biomarker of the Integrated Stress Response in the CNS, showing its correlation with ISR activity in both animal models and human patients.

This study investigates how transient reprogramming affects somatic cell identity and aging in mice, finding that it can restore youthful gene expression but also suppress identity programs.

This paper introduces a new framework to estimate in vivo protein turnover rates by addressing labeling identification and amino acid enrichment challenges, revealing differences in protein turnover between mice and naked mole-rats.