Ganesh A. Kolumam

Automated preparation of plasma lipids, metabolites, and proteins for LC/MS-based analysis of a high-fat diet in mice

The paper describes an automated LLE platform for plasma sample preparation and analyzes metabolomic, lipidomic, and proteomic changes in mice on a high-fat diet.

GDF15 is a dynamic biomarker of the Integrated Stress Response in the central nervous system

This study identifies GDF15 as a biomarker of the Integrated Stress Response in the CNS, showing its correlation with ISR activity in both animal models and human patients.

Partial reprogramming restores youthful gene expression through transient suppression of cell identity

This study investigates how transient reprogramming affects somatic cell identity and aging in mice, finding that it can restore youthful gene expression but also suppress identity programs.

Intermittent fasting and caloric restriction interact with genetics to shape physiological health in mice

This study examines how caloric restriction and intermittent fasting interact with genetics to influence physiological health in mice, finding diet-specific effects and significant genetic contributions to multiple traits.

Precise Estimation of In Vivo Protein Turnover Rates

This paper introduces a new framework to estimate in vivo protein turnover rates by addressing labeling identification and amino acid enrichment challenges, revealing differences in protein turnover between mice and naked mole-rats.