Plasticity of extrachromosomal DNA segregation during drug adaptation
Chikako Shibata, Kenichi Miyata, Marwa Akao, Kohei Kumegawa, Yumiko Maruyama, Liying Yang, Mana Nagamoto, Ryu‐Suke Nozawa, Toru Hirota, Shingo Iwami, Shoya Iwanami, Reo Maruyama
This study investigates how extrachromosomal DNA (ecDNA) copy numbers change during drug treatment, showing that resistant clones can actively reconfigure segregation behavior rather than relying on pre-existing clones.
Nature Communications · Aug 8, 2026Peer-reviewedCell Biology