Toru Hirota

This study investigates how extrachromosomal DNA (ecDNA) copy numbers change during drug treatment, showing that resistant clones can actively reconfigure segregation behavior rather than relying on pre-existing clones.

The paper shows that CCAN forms a spherical shell-like structure in interphase kinetochores using in silico and in vivo analyses.

The paper quantifies progressive changes in chromosome shape during cell divisions and finds that an alternative loop capture model explains the observed arm length to width relationship better than the loop extrusion model.

This study reveals how the chromosomal passenger complex (CPC) interacts with nucleosomes to protect centromeric chromatin, showing its non-catalytic role in maintaining chromatin stability.

This study shows that SMC5/6-mediated confinement of negative supercoils enables Top2A to resolve them during DNA replication, ensuring genome stability, and identifies over-accumulation of supercoils in cancer cells.