Author

Liying Yang

Japanese Foundation For Cancer ResearchORCID 0000-0002-4336-9014Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Liying Yang1 paper

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:scRNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Kohei KumegawaiD· 3 shared Reo MaruyamaiD· 3 shared Kenichi MiyataiD· 2 shared Akira OrimoiD· 1 shared Chikako ShibataiD· 1 shared Goro Kutomi· 1 shared Hiroko OnagiiD· 1 shared Karin Hirakuri· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

Kohei KumegawaORCID

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3 papers

Recent·Most cited

Distal-less homeobox 5 gives rise to myofibroblastic carcinoma-associated fibroblasts to promote collective breast cancer invasion

Yoshihiro Mezawa, Kohei Kumegawa, Katsuki Morita, Liying Yang, Karin Hirakuri, Kazunari Yamashita, Takuya Shirakihara, Ritsuko Sasaki, Hiroko Onagi, Goro Kutomi, Reo Maruyama, Akira Orimo

This study identifies DLX5 as a key driver of myofibroblastic carcinoma-associated fibroblasts (myCAFs) in breast cancer, showing its role in promoting tumor invasion through TGF-β signaling.

bioRxiv · Aug 31, 2026 · PreprintCancer Biology

Plasticity of extrachromosomal DNA segregation during drug adaptation

Chikako Shibata, Kenichi Miyata, Marwa Akao, Kohei Kumegawa, Yumiko Maruyama, Liying Yang, Mana Nagamoto, Ryu‐Suke Nozawa, Toru Hirota, Shingo Iwami, Shoya Iwanami, Reo Maruyama

This study investigates how extrachromosomal DNA (ecDNA) copy numbers change during drug treatment, showing that resistant clones can actively reconfigure segregation behavior rather than relying on pre-existing clones.

Nature Communications · Aug 8, 2026Peer-reviewedCell Biology

Clonal lineage tracing and parallel multiomics profiling reveal transcriptional diversification induced by ARID1A deficiency

Kenichi Miyata, Liying Yang, Yuxiao Yang, Kohei Kumegawa, Reo Maruyama

This study uses an integrated platform to show that ARID1A deficiency increases transcriptomic and epigenetic heterogeneity in cancer cells through stochastic and constrained chromatin changes.

bioRxiv · May 24, 2025 · PreprintCancer Biology