Ryu‐Suke Nozawa

This study investigates how extrachromosomal DNA (ecDNA) copy numbers change during drug treatment, showing that resistant clones can actively reconfigure segregation behavior rather than relying on pre-existing clones.

This study reveals how the chromosomal passenger complex (CPC) interacts with nucleosomes to protect centromeric chromatin, showing its non-catalytic role in maintaining chromatin stability.

This study shows that SMC5/6-mediated confinement of negative supercoils enables Top2A to resolve them during DNA replication, ensuring genome stability, and identifies over-accumulation of supercoils in cancer cells.

This paper shows that RNA and SAF-A form a microgel network in the nucleus near the sol-gel transition, exhibiting viscoelastic properties and reconciling solid-like and fluid-like behaviors.

The paper uses simulations to link 3D gene structure with transcription noise in human chromosomes, showing structural heterogeneity drives gene expression variability.

The paper investigates the chromatin structure changes during human centromere formation, finding that it involves active transcription and open chromatin, while surrounding regions become repressed and compact.

The paper shows that common fragile sites (CFSs) have faulty condensin loading leading to chromatin instability and mitotic DNA synthesis during replication stress.