Cortical Organoid Model of PPP2R5D Genetic Intellectual Disability Models Disease Severity Phenotype
Yuxin Du, Mandeep Singh, Mandar M. Patil, Isaac J. Villegas, Adriana Portillo, Kyle Shang, Roy Ben‐Shalom, Julian A. N. M. Halmai, Kyle D. Fink
This study uses cortical organoids to model PPP2R5D mutations in Jordans Syndrome, identifying gene expression, protein, and electrophysiological changes linked to disease severity.
bioRxiv · May 27, 2026 · PreprintCell Biology