Limitations in PPAR-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells
Anne C. Lietzke, Emily M. Walker, Elizabeth J. Bealer, Kelly M. Crumley, Jessica King, Ava M. Stendahl, Jie Zhu, Gemma L. Pearson, Elena Levi-D’Ancona, Belle A. Henry-Kanarek, Rebecca K. Davidson, Jin Li, Emma C. Reck, Yifei Wu, Manikanta Arnipalli, , Scott A. Soleimanpour
This study identifies PPAR-dependent mitochondrial programming as a limiting factor in the differentiation of human stem cell-derived β cells and shows that PPAR agonists can enhance β cell formation and function.
bioRxiv · Jul 26, 2024 · PreprintDevelopmental Biology