Scott A. Soleimanpour

This study shows TRAF6 regulates glucose homeostasis via mitophagy in islets, with both Parkin-dependent and -independent pathways involved.

This study identifies LONP1's role in mitochondrial protein folding and shows its impact on beta cell survival and hyperglycemia in type 2 diabetes.

This study shows that reduced mitophagy in aortic smooth muscle cells due to Parkin deficiency worsens abdominal aortic aneurysm progression.

This study identifies PPAR-dependent mitochondrial programming as a limiting factor in the differentiation of human stem cell-derived β cells and shows that PPAR agonists can enhance β cell formation and function.

This paper shows that deleting Mfn1 and Mfn2 in beta cells impairs mitochondrial structure and insulin secretion, but incretins can partially compensate through EPAC2 signaling.

This study identifies an intrinsically disordered protein region in CLEC16A critical for mitochondrial quality control and diabetes prevention.