Matrix stiffness modulated release of spheroid-derived extracellular vesicles and discovery of Piezo1 cargo
Maulee Sheth, Manju Sharma, Supasek Kongsomros, Maria A. Lehn, Takanori Takebe, Vinita Takiar, Trisha Michel Wise-Draper, Somchai Chutipongtanate, Leyla Esfandiari
This study shows that matrix stiffness modulates EV release and cargo from cancer spheroids, with stiff matrices promoting tumorigenic and metastatic profiles in EVs.
bioRxiv · Jan 13, 2025 · PreprintCancer Biology