Robert E. Braun

The paper analyzes 3,313 genetically engineered mouse lines to identify gene essentiality as the main factor affecting Cas9-based genome editing success.

This study identifies and validates 22 genes that drive drug intake and related behavioral traits in mice through knockout screening and behavioral assays.

The paper analyzes whole-genome sequencing data from Cas9-edited mice to assess off-target mutagenesis, finding minimal off-target activity across 163 guide RNAs.

The paper identifies novel Mendelian genes by analyzing mouse embryo lethality and linking them to human disease phenotypes and genetic variants.

The paper integrates gene essentiality data from human and mouse screens to classify genes into FUSIL categories, identifying developmental lethal genes associated with rare diseases.

This study identifies insertion sites in 40 transgenic mouse lines, revealing frequent disruptions of endogenous genes and structural variations.

The paper identifies 122 novel sleep-related genes from a large-scale knockout mouse study using non-invasive sleep monitoring.

The paper identifies a rare subpopulation of slow-cycling germline stem cells regulated by PLZF using RNAseq and single-cell RNA sequencing.