Extrahepatic effects of thyroid hormone and resmetirom override their beneficial hepatic effects in alcohol-associated liver disease in mice
Christoph Hoppe, Georg Sebastian Hönes, Adrian D. Prinz, Devon Siemes, Christina Wenzek, Susanne Camilla Grund, Ann-Kathrin Schörding, Yara Maria Machlah, Eveline Bruinstroop, David Laehnemann, Manuel Philipp, Karine Cécile Gauthier, Frédéric Flamant, Daniel Robert Engel, Hideo Andreas Baba, , Lars Christian Moeller
The paper shows that thyroid hormone and resmetirom have harmful extrahepatic effects in white adipose tissue that counteract their beneficial effects on the liver in alcohol-associated liver disease in mice.
bioRxiv · Oct 10, 2025 · PreprintPathology