Daniel Robert Engel

This study identifies renal mononuclear phagocytes as an intracellular reservoir for UPEC in pyelonephritis, showing that complement receptor-mediated entry promotes bacterial persistence and limits β-lactam efficacy.

The paper integrates kidney and urine proteomics with peptidomics and machine learning to identify encrypted antimicrobial peptides as functional effectors in human pyelonephritis.

This study identifies lactate as a metabolic driver of CD163+ macrophage polarization in human pyelonephritis, linking lactate metabolism to immune dysfunction.

This study shows that neutralizing extracellular histones reduces secondary brain injury and improves recovery after ischemic stroke complicated by pneumonia.

The paper identifies TSP1/TGF-β1 as a key driver of neutrophil swarming through arachidonic acid metabolism in a urinary tract infection model.

The paper shows SCAMP3 is essential for neutrophil granule formation and function, with Scamp3-deficient neutrophils showing impaired bacterial killing in vitro.

This study shows that heartbeat sound activates PIEZO channels in astrocytes, promoting extracellular matrix synthesis and neural differentiation in human brain organoids.

The paper shows that thyroid hormone and resmetirom have harmful extrahepatic effects in white adipose tissue that counteract their beneficial effects on the liver in alcohol-associated liver disease in mice.

This study identifies KDM5B's role in regulating the PRDX/TXN ROS detoxification system in melanoma DTPs, showing that PRDX inhibition increases ROS vulnerability and delays resistance to MAPK inhibition.

This study shows that the spleen produces neutrophils with distinct differentiation trajectories during stress, which are functionally competent and necessary for host defense against bacterial infection.

This study shows that CX3CR1 deficiency enhances microglial migration towards brain injury, suggesting it as a potential therapeutic target for CNS injuries.

msiFlow automates and streamlines multimodal mass spectrometry imaging and immunofluorescence data analysis to enhance reproducibility and scalability in biological research.

VesselExpress automates 3D blood vasculature analysis in LSFM data, enabling rapid and unbiased quantification of vascular parameters across multiple organs.

This study investigates the dose-dependent role of Gfi1 in murine hematopoietic stem cell self-renewal and differentiation, finding that reduced Gfi1 levels impair myeloid and lymphoid differentiation.