Georg Sebastian Hönes

ALK Inhibition Prolongs Survival in a Mouse Model of ALK-positive Anaplastic Thyroid Cancer

Short-term but not long-term triiodothyronine treatment improved cardiac function after myocardial infarction in male wild-type mice

This study shows short-term T3 treatment improves cardiac function after MI in WT mice, while long-term T3 causes hypertrophy without functional benefit and may worsen function in TR-deficient mice.

Extrahepatic effects of thyroid hormone and resmetirom override their beneficial hepatic effects in alcohol-associated liver disease in mice

The paper shows that thyroid hormone and resmetirom have harmful extrahepatic effects in white adipose tissue that counteract their beneficial effects on the liver in alcohol-associated liver disease in mice.

Advancing molecular, phenotypic and mechanistic insights of FGF14 pathogenic expansions (SCA27B)

This study identifies the complete sequences of pathogenic and non-pathogenic FGF14 repeat expansions in patients with cerebellar ataxia, revealing a lower pathogenic threshold and providing mechanistic insights into disease causation.