Tunable Universal OR-gated CAR T cells for AML
Md Nure Alom Siddiqui, Jingyao Chen, Juanjuan Huang, Madeline K. Loffredo, Seunghee Lee, Han Deng, Yongshuai Li, Nelia Leemans, Tim Lu, Brian S. Garrison, Marcela Guzman Ayala, Nicholas W. Frankel, Wilson W. Wong
This study develops a tunable OR-gated CAR system for AML treatment that effectively targets multiple antigens with reduced engineering complexity and minimized off-target toxicity.
iScience · Aug 1, 2026Peer-reviewedSynthetic Biology