Jingyao Chen

This study develops a tunable OR-gated CAR system for AML treatment that effectively targets multiple antigens with reduced engineering complexity and minimized off-target toxicity.

The paper introduces CRIBOS, a cell-free genetic circuit platform for multiplex Boolean logic, demonstrating environmental sensing and long-term DNA memory storage.

This paper introduces CRISTAL, a platform for programmable RNA regulation using inducible Cas13 circuits, enabling precise temporal control and multiplexed gene regulation in mammalian cells.