Nek family members regulate Rad54 during homologous recombination in developing mice
Isabel Freund, Jie Liu, Holly Thomas, Mareike Haarmann, Emilie Renaud, Florian Frohns, Jia-Xuan Chen, Wolf‐Dietrich Heyer, Markus Löbrich
This study shows that Nek1 regulates Rad54 phosphorylation at Ser572 to promote HR in adult mice but not in embryos, with Nek3 and Nek5 compensating in embryonic cells.
bioRxiv · Dec 22, 2025 · PreprintCell Biology