Wolf‐Dietrich Heyer

This study investigates how Rad55-Rad57 and Srs2 regulate homology search in yeast by controlling Rad51-ssDNA filament stability and coordination.

This paper defines the role of RAD54B in homologous recombination using cryo-EM and biochemical assays, showing it stabilizes RAD51 filaments and promotes D-loop formation.

This study identifies Rad51 mutations that shift post-replication repair pathway usage from homologous recombination to alternate pathways by affecting fork protection.

This study shows that Nek1 regulates Rad54 phosphorylation at Ser572 to promote HR in adult mice but not in embryos, with Nek3 and Nek5 compensating in embryonic cells.

This study investigates the role of H2B mono-ubiquitylation in homologous recombination repair by analyzing its effects on D-loop metabolism and chromatin dynamics in S. cerevisiae.

This paper uses cryo-EM to determine the structure of Rad51-ssDNA filaments in budding yeast, revealing local structural dynamics and conformational changes in Rad51 protomers.

This study identifies how Mec1/ATR kinase controls homologous recombination to suppress gross chromosomal rearrangements through Rad53 and Sgs1 pathways.

The paper identifies two distinct pathways of genome rearrangement induced by multi-invasion during homologous recombination and their impact on genome stability.

This study develops an assay to detect D-loops in vivo, revealing their formation kinetics and two distinct pathways for their disruption involving Srs2 and Mph1/Sgs1-Top3-Rmi1 complexes.