From bats to humans: uncovering ISG15 as a new resistance factor in type 1 diabetes
Eugenia Martín-Vázquez, Xiaoyan Yi, Maressa Fernandes Bonfim, Sayro Jawurek, Priscila Laiz Zimath, Arturo Roca-Rivada, Junior Garcia Oliveira, José Maria Costa-Júnior, François N. Pattou, Julie A. Kerr-Conte, Montserrat Nacher, Eduard Montanya, Erwin Ilegems, Johnna D. Wesley, Alexandra C. Title, , Decio Laks Eizirik
The paper identifies ISG15 as a key factor in viral resistance in pancreatic alpha cells, showing its protective role against coxsackievirus B1 in human islet cells.
bioRxiv · Apr 6, 2026 · PreprintImmunology