Author

Alexandra C. Title

ORCID 0009-0004-9289-0836Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Burçak YesildagiD· 3 shared Erwin IlegemsiD· 3 shared Sayro JawurekiD· 3 shared Decio Laks EizirikiD· 2 shared Eugenia Martín-VázqueziD· 2 shared Johnna D. WesleyiD· 2 shared José Maria Costa-JúnioriD· 2 shared Junior Garcia OliveiraiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Burçak YesildagORCID

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4 papers

Recent·Most cited

Targeting PFKFB3 Metabolic Gatekeeping of β-Cell Dysfunctional States Enables Durable Glucose Tolerance in Type 2 Diabetes

Kavit Raval, Erwin Ilegems, Alexandra C. Title, Emme Fishburn, Gurprit Bhardwaj, Olivier Mirguet, Paul D. Ratcliffe, Oppel B.W. Greeff, Abraham van Wyk, Slavica Tudzarova

This study shows that inhibiting PFKFB3 improves glucose tolerance in type 2 diabetes by restoring β-cell function and reducing dysfunctional states, with effects lasting after treatment stops.

bioRxiv · Sep 22, 2026 · PreprintCell Biology

From bats to humans: uncovering ISG15 as a new resistance factor in type 1 diabetes

Eugenia Martín-Vázquez, Xiaoyan Yi, Maressa Fernandes Bonfim, Sayro Jawurek, Priscila Laiz Zimath, Arturo Roca-Rivada, Junior Garcia Oliveira, José Maria Costa-Júnior, François N. Pattou, Julie A. Kerr-Conte, Montserrat Nacher, Eduard Montanya, Erwin Ilegems, Johnna D. Wesley, Alexandra C. Title, , Decio Laks Eizirik

The paper identifies ISG15 as a key factor in viral resistance in pancreatic alpha cells, showing its protective role against coxsackievirus B1 in human islet cells.

bioRxiv · Apr 6, 2026 · PreprintImmunology

Differential immune- and apoptosis-related gene signatures in pancreatic alpha and beta cells contribute to their fate in type 1 diabetes

Xiaoyan Yi, Eugenia Martín-Vázquez, Sayro Jawurek, Priscila Laiz Zimath, Junior Garcia Oliveira, José Maria Costa-Júnior, Erwin Ilegems, Johnna D. Wesley, Alexandra C. Title, Burçak Yesildag, Decio Laks Eizirik

Cell Death and Differentiation · Jan 30, 2026Peer-reviewedCell Biology

Proinflammatory cytokine-induced alpha-cell impairment in human islet microtissues is partially restored by dual incretin receptor agonism

Kristine Henriksen, Chantal Rufer, Alexandra C. Title, Sayro Jawurek, Bolette Hartmann, Jens Juul Holst, Filip Krag Knop, Burçak Yesildag, Joachim Størling

This paper shows that long-term cytokine exposure impairs alpha-cell glucagon secretion in human islet microtissues, which is partially restored by dual incretin receptor agonists.

Diabetologia · May 15, 2025Peer-reviewedCell Biology