The S2 subunit of spike encodes diverse targets for functional antibody responses to SARS-CoV-2
Jamie Guenthoer, Meghan E. Garrett, Michelle Lilly, Delphine Depierreux, Felicitas Ruiz, Margaret Chi, Caitlin I. Stoddard, Vrasha Chohan, Zak A. Yaffe, Kevin Sung, Duncan Ralph, Helen Y. Chu, Frederick A. Matsen IV, Julie M. Overbaugh
This paper identifies diverse functional antibodies targeting the S2 subunit of SARS-CoV-2 spike, including one with broad neutralization activity across multiple coronaviruses.
PLoS Pathogens · Aug 2, 2024Peer-reviewedImmunology