Author

Delphine Depierreux

Fred Hutch Cancer CenterORCID 0000-0002-1402-5394Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Felicitas RuiziD· 3 shared Jamie Guenthoer· 3 shared Julie M. OverbaughiD· 3 shared Michelle LillyiD· 3 shared Vrasha Chohan· 3 shared Duncan RalphiD· 2 shared Helen Y. ChuiD· 2 shared Paul D. BieniasziD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Felicitas RuizORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Determinants of Natural Killer Cell-Mediated Antibody Dependent Cellular Cytotoxicity in SARS-CoV-2 Antibodies

Delphine Depierreux, Felicitas Ruiz, Michelle Lilly, Jamie Guenthoer, Vrasha Chohan, Julie M. Overbaugh

This study identifies epitope targeting as the main determinant of ADCC activity in SARS-CoV-2 antibodies, showing that moderate binding and not SHM or neutralization potency drives immune cell activation.

PLoS Pathogens · Mar 12, 2026Peer-reviewedImmunology

Re-infection with SARS-CoV-2 is associated with increased antibody breadth and potency against diverse sarbecovirus strains

Michelle Lilly, Felicitas Ruiz, William B. Foreman, Vrasha Chohan, Jamie Guenthoer, Delphine Depierreux, Viren A. Baharani, Duncan Ralph, Alex Harteloo, Helen Y. Chu, Paul D. Bieniasz, Tyler N. Starr, Julie M. Overbaugh

This study shows that re-infection with SARS-CoV-2 leads to broader and more potent antibodies against diverse sarbecovirus strains compared to antibodies from a prior infection.

mBio · Feb 25, 2026Peer-reviewedImmunology

Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development

Natalie Samper, Lilja Harðardóttir, Delphine Depierreux, Soomin C. Song, Ayano Nakazawa, Ivan Gando, Tomoe Y. Nakamura, Andrew Sharkey, Carla R. Nowosad, Stefan Feske, Francesco Colucci, William A. Coetzee

This study identifies Kir6.1 as a key regulator of natural killer cell development in mice, showing its expression in mature NK cells and its role in NK-cell differentiation.

Frontiers in Immunology · Dec 2, 2024Peer-reviewedImmunology

Delineating the functional activity of antibodies with cross-reactivity to SARS-CoV-2, SARS-CoV-1 and related sarbecoviruses

Felicitas Ruiz, William B. Foreman, Michelle Lilly, Viren A. Baharani, Delphine Depierreux, Vrasha Chohan, Ashley L. Taylor, Jamie Guenthoer, Duncan Ralph, Frederick A. Matsen IV, Helen Y. Chu, Paul D. Bieniasz, Marceline Côté, Tyler N. Starr, Julie M. Overbaugh

This study identifies cross-reactive antibodies against SARS-CoV-2 and related sarbecoviruses that target conserved epitopes and show broad neutralization potential.

PLoS Pathogens · Oct 28, 2024Peer-reviewedImmunology