Argonaute-siRNA loading via the RNA-binding protein RDE-4 in C. elegans
Thiago L. Knittel, Brooke E Montgomery, Reese A Sprister, Colin N Magelky, Margaret J Smith, Maritza Soto-Ojeda, Melissa Guthrie, Carolyn M. Phillips, Taiowa A. Montgomery
This study identifies RDE-4 as a key factor in loading siRNAs into RDE-1 and 26G-RNAs into ERGO-1 in C. elegans, revealing its role in small RNA loading specificity.
Current Biology · Nov 18, 2025Peer-reviewedBiochemistry