Carolyn M. Phillips

The paper identifies new germ granule proteins in C. elegans and shows their roles in RNAi and small RNA inheritance, with PINT-1 being critical for siRNA biogenesis.

The paper uses LC-MS proteomics to identify PRMT-1 substrates and quantify proteome changes in C. elegans prmt-1 and prmt-5 knockout mutants.

The paper shows that unloaded Argonaute proteins in C. elegans are degraded by the ubiquitin-proteasome system, highlighting a quality control mechanism for small RNA-loaded Argonautes.

This study identifies RDE-4 as a key factor in loading siRNAs into RDE-1 and 26G-RNAs into ERGO-1 in C. elegans, revealing its role in small RNA loading specificity.

This study identifies RG motifs in C. elegans PRG-1 as critical for linking piRNA-mediated silencing to siRNA production, impacting fertility and germline maintenance.

The paper shows NRDE-3 switches small RNA partners during embryogenesis to regulate gene expression in somatic cells.

The paper shows that HRDE-2 mediates the localization of HRDE-1 to germ granules, which is essential for its specific binding to small RNAs and proper gene silencing in C. elegans.

The paper shows that arginine methylation in CSR-1A enables specific binding of 22G-RNAs associated with spermatogenesis, distinguishing it from CSR-1B which binds oogenesis-related RNAs.

This study identifies factors regulating Mutator foci in C. elegans germline cells across developmental stages and cell cycle phases.

This study identifies ZNFX-1 and WAGO-4 as key proteins for RNA-directed transgenerational epigenetic inheritance in C. elegans, showing their localization to liquid droplet structures and their role in maintaining siRNA expression across generations.