Enhancing lysosome function via mTOR/TFEB activation reduces lipofuscin-like granules in early Age-related Macular Degeneration
Ana S. Falcão, Mafalda Lopes‐da‐Silva, Pedro Antas, Cristina Escrevente, Margarida Pedro, Rita Coelho, Inês S. Ferreira, Inês Paz Santos, Thomas Ciossek, Paul L. Nicklin, Sandra Tenreiro, Miguel C. Seabra
This study shows that activating the mTOR/TFEB pathway reduces lipofuscin-like granules in AMD by improving lysosomal function and POS digestion.
bioRxiv · Sep 17, 2024 · PreprintMolecular Biology