Author

Miguel C. Seabra

Universidade Nova de LisboaORCID 0000-0002-6404-4892Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Cristina EscreventeiD· 2 shared Duarte C. BarraliD· 2 shared Inês Paz SantosiD· 2 shared Inês S. FerreiraiD· 2 shared Mafalda Lopes‐da‐SilvaiD· 2 shared Matilde V. NetoiD· 2 shared Michael J. HalliD· 2 shared Pedro AntasiD· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersMolecular Biology

Cristina EscreventeORCID

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Author profile →

5 papers

Recent·Most cited

Enhancing lysosome function via mTOR/TFEB activation reduces lipofuscin-like granules in early Age-related Macular Degeneration

Ana S. Falcão, Mafalda Lopes‐da‐Silva, Pedro Antas, Cristina Escrevente, Margarida Pedro, Rita Coelho, Inês S. Ferreira, Inês Paz Santos, Thomas Ciossek, Paul L. Nicklin, Sandra Tenreiro, Miguel C. Seabra

This study shows that activating the mTOR/TFEB pathway reduces lipofuscin-like granules in AMD by improving lysosomal function and POS digestion.

bioRxiv · Sep 17, 2024 · PreprintMolecular Biology

Photoprotective melanin is maintained within keratinocytes in a storage lysosome

Matilde V. Neto, Michael J. Hall, João Charneca, Cristina Escrevente, Miguel C. Seabra, Duarte C. Barral

The paper shows melanin-containing phagosomes in keratinocytes mature into storage lysosomes called melanokerasomes, which retain melanin for long-term photoprotection.

bioRxiv · Feb 5, 2024Cell Biology

3D human retinal organoid model for the study of early diabetic retinopathy

Luísa de Lemos, Pedro Antas, Inês S. Ferreira, Inês Paz Santos, Catarina Monteiro Gomes, Catarina Brito, Miguel C. Seabra, Sandra Tenreiro

This paper develops a 3D human retinal organoid model to study early diabetic retinopathy and identifies molecular and cellular features associated with the disease.

bioRxiv · Sep 4, 2023 · PreprintNeuroscience

Deacidification of distal lysosomes by neuronal aging drives synapse loss

Tatiana Burrinha, César Cunha, Michael J. Hall, Mafalda Lopes‐da‐Silva, Miguel C. Seabra, Cláudia Guimas Almeida

The paper identifies deacidification of distal lysosomes in aged neurons as a mechanism driving synapse loss and shows that restoring acidification can reverse synaptic decline.

Traffic · May 23, 2023Peer-reviewedNeuroscience

Rab3a regulates melanin exocytosis induced by keratinocyte-conditioned medium

Luís C. Cabaço, Liliana Bento‐Lopes, Matilde V. Neto, Jose Silva Ramalho, Miguel C. Seabra, Duarte C. Barral

This study identifies Rab3a as a regulator of melanin exocytosis in melanocytes stimulated by keratinocyte-conditioned medium, revealing a distinct pathway from Rab11b-dependent exocytosis.

bioRxiv · May 24, 2021 · PreprintMolecular Biology