Author

Mafalda Lopes‐da‐Silva

Universidade Nova de LisboaORCID 0000-0001-7651-8656Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Miguel C. SeabraiD· 2 shared Ana S. FalcãoiD· 1 shared César CunhaiD· 1 shared Cláudia Guimas AlmeidaiD· 1 shared Cristina EscreventeiD· 1 shared Inês Paz SantosiD· 1 shared Inês S. FerreiraiD· 1 shared Margarida Pedro· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Miguel C. SeabraORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 17, 2024

Enhancing lysosome function via mTOR/TFEB activation reduces lipofuscin-like granules in early Age-related Macular Degeneration

Ana S. Falcão, Mafalda Lopes‐da‐Silva, Pedro Antas…·Miguel C. Seabra

This study shows that activating the mTOR/TFEB pathway reduces lipofuscin-like granules in AMD by improving lysosomal function and POS digestion.

1 citation

humanbulk RNA-seq

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NeuroscienceTrafficPeer-reviewedMay 23, 2023

Deacidification of distal lysosomes by neuronal aging drives synapse loss

Tatiana Burrinha, César Cunha, Michael J. Hall…·Cláudia Guimas Almeida

The paper identifies deacidification of distal lysosomes in aged neurons as a mechanism driving synapse loss and shows that restoring acidification can reverse synaptic decline.

35 citationstop 3%

mouseexperimental assay

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