Specificity and Mechanism of tRNA cleavage by the AriB Toprim nuclease of the PARIS bacterial immune system
Svetlana Belukhina, Baptiste Saudemont, Florence Depardieu, Tom Lorthios, Tinashe P. Maviza, Alexei Livenskyi, Marina V. Serebryakova, Maria Aleksandrova, Elizaveta Ukholkina, Nadezhda R. Burmistrova, Сергиев Петр Владимирович, Marouane Libiad, Sarah Dubrac, Frédéric Barras, Yuri Motorin, , Christophe Rouillon
The paper identifies additional tRNA targets of the AriB nuclease in the PARIS system and shows that phage-encoded tRNAs can inhibit this defense.
Philosophical Transactions of the Royal Society B Biological Sciences · Sep 4, 2025Peer-reviewedMicrobiology