The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states
Milena Doroszko, Rebecka Stockgard, Irem Uppman, Josephine Heinold, Faidra Voukelatou, Hitesh Bhagavanbhai Mangukiya, Thomas O Millner, Madeleine Skeppås, Mar Ballester Bravo, Ramy Elgendy, Maria Berglund, Ludmila Elfineh, Cecilia C. Krona, Soumi Kundu, Katarzyna Koltowska, , Sven Nelander
This study identifies cell state-specific regulators of glioblastoma invasion routes using single-cell transcriptomics and spatial proteomics, showing their impact on patient survival and therapeutic potential.
Nature Communications · Jul 19, 2025Peer-reviewedCancer Biology