Hitesh Bhagavanbhai Mangukiya

A Multi-Omic Phenobank Reveals Axes of Glioblastoma Growth, Invasion, and Therapeutic Vulnerability

The paper establishes a multi-omic PDX resource linking GBM invasion phenotypes to molecular programs and therapeutic responses, identifying two invasion modes and a neurodevelopmental factor associated with tumor growth and survival.

The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states

This study identifies cell state-specific regulators of glioblastoma invasion routes using single-cell transcriptomics and spatial proteomics, showing their impact on patient survival and therapeutic potential.

Brain tumor induce immunoregulatory dendritic cells in tumor draining lymph nodes that can be targeted by OX40

This study identifies immunoregulatory dendritic cells in brain tumor draining lymph nodes and shows OX40 can target them to improve immunotherapy.

Reconstructing the Single-Cell Spatiotemporal Dynamics of Glioblastoma Invasion

This paper introduces GlioTrace, an ex vivo imaging and AI framework to track glioblastoma invasion dynamics in patient-derived brain slices, revealing patient-specific invasion patterns and drug responses.