Ramy Elgendy

A Multi-Omic Phenobank Reveals Axes of Glioblastoma Growth, Invasion, and Therapeutic Vulnerability

The paper establishes a multi-omic PDX resource linking GBM invasion phenotypes to molecular programs and therapeutic responses, identifying two invasion modes and a neurodevelopmental factor associated with tumor growth and survival.

DNA Damage Driven Viability Loss and Transcriptional Reprogramming in Chinese Hamster Ovary Cell Perfusion Culture

The paper identifies DNA damage accumulation as a key factor limiting viability in Chinese hamster ovary cells during perfusion culture, showing impaired DNA damage response and transcriptional dysfunction.

The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states

This study identifies cell state-specific regulators of glioblastoma invasion routes using single-cell transcriptomics and spatial proteomics, showing their impact on patient survival and therapeutic potential.

Identification of Cellular Signatures Associated with Chinese Hamster Ovary (CHO) Cell Adaptation for Secretion of Antibodies

This study identifies cellular adaptations in CHO cells linked to antibody production, finding that transgene copy number and mRNA expression levels are key factors in productivity.