Katarzyna Koltowska

Reconstruction of the Prox gene family evolution in vertebrates reveals multiple lineage-specific gene losses

This study reconstructs the evolutionary history of the Prox gene family in vertebrates, revealing lineage-specific gene losses and identifying a fourth ancestral Prox gene.

Integrin β1-Talin1 at focal adhesions underpin uncontrolled endothelial cell enlargement in live cerebral cavernous malformation vasculature

This study shows integrin β1-Talin1 at focal adhesions drive uncontrolled endothelial cell enlargement in CCM vasculature, independent of KLF2/4.

The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states

This study identifies cell state-specific regulators of glioblastoma invasion routes using single-cell transcriptomics and spatial proteomics, showing their impact on patient survival and therapeutic potential.

Distinct topologically associated domains underlie the regulatory logic in lymphatic endothelial cells contributing to proper cell differentiation

This study identifies cell type-specific topologically associated domains in lymphatic endothelial cells and defines regulatory networks contributing to their differentiation.

Multiple cis-regulatory elements control prox1a expression in distinct lymphatic vascular beds

This study identifies multiple cis-regulatory elements controlling prox1a expression in distinct lymphatic vascular beds in zebrafish.

Single cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development

This study uses single-cell transcriptomics to investigate Prox1's role in lymphatic endothelial cell fate specification and differentiation in zebrafish, identifying new transcriptional targets and regulatory mechanisms.

Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells

This study identifies that arterial mural cells provide survival and guidance cues via Cxcl12a/b and Vegfc to promote lymphatic endothelial cell migration in zebrafish.

Vasohibin-1 mediated tubulin detyrosination selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk

This study shows that Vasohibin-1 mediates tubulin detyrosination in zebrafish endothelial cells, selectively regulating secondary sprouting and lymphangiogenesis in the trunk.