Learning the dynamic organization of a replicating bacterial chromosome from time-course Hi-C data
Janni Harju, Joris J. B. Messelink, Lucas Tröger, Grzegorz Gradziuk, Imesha Rathnayaka, Maria Billini, Martin R. Thanbichler, Muriel C. F. van Teeseling, Chase P. Broedersz
The paper develops a 4D Maximum Entropy model to analyze time-course Hi-C data and reveals dynamic chromosome organization in Caulobacter crescentus during replication.
bioRxiv · Apr 3, 2025 · PreprintBiophysics