Gert Bange

This study shows that the YqeK hydrolase regulates Ap4A levels in S. aureus, affecting growth, stress survival, biofilm formation, and virulence.

This study investigates whether NUDT2 loss and subsequent Ap4A accumulation affects the cGAS-STING-TBK1 pathway, finding that physiological levels of Ap4A do not inhibit the pathway.

This paper discovers NHAP, a fungal metabolite that selectively inhibits Gi-signaling, demonstrating functional blockade in cardiomyocytes without cytotoxicity.

This study investigates how mutations at the oligomerization interface of Sudan virus VP40 affect its structural properties and functional roles in viral RNA synthesis and budding.

The paper identifies Acl1 and Bcl1 as dedicated chaperones for Rpl1 by using proximity labeling and structural analysis in yeast.

This paper develops photocaged MSN analogues that can be delivered into E. coli, photo-released, and tracked to study their metabolic effects.

This paper identifies the quinone-binding pocket of SaMhqR and elucidates its mechanism of inactivation through structural and mutational analyses.

This study investigates how ParB activates ParA ATPase activity during bacterial chromosome segregation in Myxococcus xanthus by analyzing their molecular interactions.

The paper identifies ligand specificities of chemosensory receptors in the human gut microbiota, revealing key metabolites like lactate and formate as important signals.

The paper identifies a synthetic small molecule, C26, that inhibits HilD, a key regulator of Salmonella secretion systems, thereby preventing bacterial invasion of host cells.

This study identifies allosteric regulation of pyruvate kinase in Bacillus subtilis as critical for efficient gluconeogenesis by preventing metabolic conflicts and carbon overflow.

The paper investigates the evolutionary dynamics of self-assembly in prokaryotic citrate synthases, finding frequent transitions between different assembly types without strong functional consequences.

This study investigates the role of cpSRP54 domains and its C-terminal tail in chloroplast protein transport, showing their importance in post- and cotranslational transport of photosynthetic proteins.

This study identifies the membrane-targeting sequence of bactofilin BacA and reveals its molecular mechanism, conservation across bacterial species, and functional interplay with polymerization and client protein recruitment.

This study identifies how FlhF and FlhG regulate flagellar assembly by anchoring structures to the cell pole via interactions with HubP and FliG.