Wieland Steinchen

This paper discovers NHAP, a fungal metabolite that selectively inhibits Gi-signaling, demonstrating functional blockade in cardiomyocytes without cytotoxicity.

This study investigates the conformational dynamics of the membrane-anchored foldase LipH and shows how it recognizes, folds, and releases its client lipase LipA.

This study investigates how mutations at the oligomerization interface of Sudan virus VP40 affect its structural properties and functional roles in viral RNA synthesis and budding.

This study identifies an E3-HTL-substrate complex that reveals how strigolactone perception by the receptor HTL7 is linked to substrate recognition by the E3 ubiquitin ligase MAX2.

This study investigates how ParB activates ParA ATPase activity during bacterial chromosome segregation in Myxococcus xanthus by analyzing their molecular interactions.

This study identifies Jps1 as a key protein facilitating unconventional secretion in Ustilago maydis by interacting with phosphoinositides, revealing its structural and functional roles in Cts1 export.

The paper identifies a synthetic small molecule, C26, that inhibits HilD, a key regulator of Salmonella secretion systems, thereby preventing bacterial invasion of host cells.

This study identifies allosteric regulation of pyruvate kinase in Bacillus subtilis as critical for efficient gluconeogenesis by preventing metabolic conflicts and carbon overflow.

The paper shows that multiple mechanisms of essentiality in protein-protein interactions can persist over time, even if individual mechanisms are lost, using Rubisco as a case study.

This study identifies the membrane-targeting sequence of bactofilin BacA and reveals its molecular mechanism, conservation across bacterial species, and functional interplay with polymerization and client protein recruitment.