Buffer Valency Engineering Enables High-concentration and Shelf-stable DNA Transfection Particles for Viral Vector Production
Jinghan Lin, Yizong Hu, Turash Haque Pial, Kailei D. Goodier, Di Yu, Marine Guise, Paetra Brailsford, Maria Choi-Ali, Sixuan Li, Yining Zhu, Jingyao Ma, Leonardo Cheng, Xiaoya Lu, Nicole Korinetz, Jeff Wang, , Hai‐Quan Mao
This paper develops a method to create high-concentration, shelf-stable DNA transfection particles for AAV production, achieving tenfold higher pDNA concentration and reduced dosing volume.
bioRxiv · Jul 2, 2025 · PreprintBiochemistry