BiochemistrybioRxivPreprint
Buffer Valency Engineering Enables High-concentration and Shelf-stable DNA Transfection Particles for Viral Vector Production
Jinghan Lin, Yizong Hu, Turash Haque Pial…·Hai‐Quan Mao
This paper develops a method to create high-concentration, shelf-stable DNA transfection particles for AAV production, achieving tenfold higher pDNA concentration and reduced dosing volume.
DOI 10.1101/2025.07.02.662322