Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors
Chiara Bosetti, Dionysis Kampasis, Shoshy Alam Brinch, Albert Galera‐Prat, Maria Karelou, Saurabh Singh Dhakar, Juho Alaviuhkola, Jo Waaler, Lari Lehtiö, Ioannis K. Kostakis
This study identifies C-8 position substitutions in quinazolin-4-ones that enhance the potency and selectivity of tankyrase inhibitors by improving interactions with TNKS2.
European Journal of Medicinal Chemistry · Feb 15, 2025Peer-reviewedBiochemistry