Chiara Bosetti

The paper identifies a Tankyrase scaffolding inhibitor, S8 (ARCher-142), that selectively targets the ARC4 peptide binding domain with 8 µM potency.

This study identifies C-8 position substitutions in quinazolin-4-ones that enhance the potency and selectivity of tankyrase inhibitors by improving interactions with TNKS2.

This study investigates the evolutionary origin and conservation of tankyrases across species, showing their presence in choanoflagellates and conservation of core functions despite varying interaction partners.