Author

Maria Luisa J Amaral

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 1

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:snRNA-seq· 1

Frequent Co-Authors

Bing ReniD· 1 shared Dai-Hua CheniD· 1 shared M.D. Neranjan TharukaiD· 1 shared Nikhil ChilakapatiiD· 1 shared Shih‐Ting HuangiD· 1 shared Stephen Philip SchoenbergeriD· 1 shared Tianchen ReniD· 1 shared Ye ZhengiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperImmunology

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1 paper

Recent·Most cited

ImmunologyScience AdvancesPeer-reviewedOct 9, 2026

SUMO2 Deletion Changes Chromatin Accessibility and Enhances Cytotoxic T Cell Activation and Tumor Infiltration

M.D. Neranjan Tharuka, Dai-Hua Chen, Maria Luisa J Amaral…·Yuan Chen

This study shows that deleting SUMO2 in CD8+ T cells enhances their activation, tumor infiltration, and anti-tumor effects by altering chromatin accessibility and gene expression.

DOI 10.1126/sciadv.aef2217

mousehuman

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