Author

Dai-Hua Chen

University of California San DiegoORCID 0000-0001-5785-6895Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

M.D. Neranjan TharukaiD· 2 shared Tianchen ReniD· 2 shared Yixuan KuangiD· 2 shared Yuan CheniD· 2 shared Bing ReniD· 1 shared Helene L. GrosiD· 1 shared Himangshu SonowaliD· 1 shared Jorge De la TorreiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

M.D. Neranjan TharukaORCID

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2 papers

Recent·Most cited

ImmunologyScience AdvancesPeer-reviewedOct 9, 2026

SUMO2 Deletion Changes Chromatin Accessibility and Enhances Cytotoxic T Cell Activation and Tumor Infiltration

M.D. Neranjan Tharuka, Dai-Hua Chen, Maria Luisa J Amaral…·Yuan Chen

This study shows that deleting SUMO2 in CD8+ T cells enhances their activation, tumor infiltration, and anti-tumor effects by altering chromatin accessibility and gene expression.

DOI 10.1126/sciadv.aef2217

mousehuman

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Cancer BiologyMolecular Cancer TherapeuticsPeer-reviewedDec 3, 2025

Immunomodulation of Pancreatic Cancer via Inhibition of SUMOylation and CD155/TIGIT Pathway

Jorge De la Torre, Utsav Joshi, Himangshu Sonowal…·Rebekah Ruth White

This study shows that combining SUMO E1 inhibition with TIGIT blockade enhances anti-tumor immunity in pancreatic cancer by reducing regulatory T cells and improving T cell reactivity.

5 citations

mouseexperimental assay

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