Ye Zheng

This study shows that deleting SUMO2 in CD8+ T cells enhances their activation, tumor infiltration, and anti-tumor effects by altering chromatin accessibility and gene expression.

This study identifies IL-27 as an inducer of a distinct CD4+ cytotoxic T cell program that differs from Th1 lineage.

This study identifies CA19-9's role in remodeling the PDAC tumor microenvironment by inducing IL1a and TGFb, leading to immunosuppressive changes that can be mitigated by blocking these factors.

This study identifies CREB/CRTC2 as a regulator of GPR65 in Th17 cells, showing its role in metabolic fitness and pathogenic function through RNA-seq and chromatin immunoprecipitation.

This study identifies serine dehydratase (Sds) as a regulator of serine and sphingolipid metabolism, showing that its deletion improves skin repair in diabetic mice.

This study identifies how RORγt mutations affect gene activation by altering chromatin binding modes, explaining context-dependent autoimmunity and host defense outcomes.

This study shows that PPARδ limits CIITA-MHC II expression in Tregs, reducing their immunosuppressive function and enhancing anti-tumor responses.