Pathobiont-triggered induction of epithelial IDO1 drives regional susceptibility to Inflammatory Bowel Disease
Paige N Spencer, Jiawei Wang, Erin P. Smith, Luisella Spiga, Alan J. Simmons, Tae Woo Kim, William Kim, Monica E Brown, Yilin Yang, Harsimran Kaur, Yanwen Xu, Seungwoo Kang, Matthew D Helou, Mason A. Lee, Lin Zheng, , Ken S. Lau
The paper identifies a pathobiont-epithelial IDO1 pathway that drives region-specific susceptibility to inflammatory bowel disease in the ascending colon.
bioRxiv · Jan 4, 2025 · PreprintCell Biology