Harsimran Kaur

The paper develops an optimized multimodal imaging workflow that preserves tissue integrity and enables comprehensive profiling of morphology, collagen, cell populations, N-glycans, and extracellular matrix peptides from a single tissue section.

The paper creates a spatial atlas of early-stage colorectal cancer tumors to identify bacterial niches and their impact on tumor transcriptomes, highlighting C. difficile's significant influence despite low abundance.

This study shows HbC in HbSC disease causes more oxidative denaturation and RBC membrane damage than HbS, with hydroxyurea and quercetin reducing these effects.

PoweREST estimates statistical power for detecting differentially expressed genes in spatial transcriptomics experiments using 10X Genomics Visium data.

This study shows that microbiota enhance CD39 expression in γδ IELs via TCR and IL-15 signaling, leading to regulatory IEL expansion and reduced inflammation.

The paper identifies a pathobiont-epithelial IDO1 pathway that drives region-specific susceptibility to inflammatory bowel disease in the ascending colon.

The paper introduces MILWRM, a tool for detecting tissue domains in spatial-omics data, and demonstrates its application in human colonic polyps and mouse brain slices.

The paper identifies a novel epithelial cell type, LND, in Crohn's disease that is associated with immune dysregulation and disease activity.

GammaGateR provides a semi-automated marker gating tool for multiplexed imaging data, improving consistency and reducing manual effort while revealing biological signals.

This study maps tumor evolution and microenvironment dynamics in colorectal cancer using spatial multi-omic data, identifying key genes associated with immune exclusion and prognosis.