Author

Jeremy A. Goettel

Vanderbilt UniversityORCID 0000-0002-0749-2357Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alan J. SimmonsiD· 2 shared Harsimran KauriD· 2 shared Jennifer M. PilatiD· 2 shared Justin JacobseiD· 2 shared Keith T. WilsoniD· 2 shared Ken S. LauiD· 2 shared Lori A. CoburniD· 2 shared Mary Kay WashingtoniD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Alan J. SimmonsORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Trsp is required by regulatory T cells to prevent lethal autoimmunity in mice

Justin Jacobse, Jennifer M. Pilat, Anna Brooke Harris, Aaron Kwag, Zaryab Aziz, Channing Chi, Sam Schaefer, M. Diana Neely, Matthew A. Buendia, Andrew P Pahnke, Christopher S. Williams, Wentao Deng, M. Kay Washington, Jeffrey C. Rathmell, Charles Robb Flynn, , Yash A. Choksi

This study shows that Trsp is essential for T cell development and function, particularly regulatory T cells, and its deficiency leads to fatal autoimmunity.

bioRxiv · Sep 9, 2025 · PreprintImmunology

Pathobiont-triggered induction of epithelial IDO1 drives regional susceptibility to Inflammatory Bowel Disease

Paige N Spencer, Jiawei Wang, Erin P. Smith, Luisella Spiga, Alan J. Simmons, Tae Woo Kim, William Kim, Monica E Brown, Yilin Yang, Harsimran Kaur, Yanwen Xu, Seungwoo Kang, Matthew D Helou, Mason A. Lee, Lin Zheng, , Ken S. Lau

The paper identifies a pathobiont-epithelial IDO1 pathway that drives region-specific susceptibility to inflammatory bowel disease in the ascending colon.

bioRxiv · Jan 4, 2025 · PreprintCell Biology

A Specialized Epithelial Cell Type Regulating Mucosal Immunity and Driving Human Crohn's Disease

Jia Li, Alan J. Simmons, Caroline V. Hawkins, Sophie Chiron, Marisol A Ramirez-Solano, Naila Tasneem, Harsimran Kaur, Yanwen Xu, Frank L. Revetta, Paige N. Vega, Shunxing Bao, Can Cui, Regina N. Tyree, Larry W. Raber, Anna N. Conner, , Qi Liu

The paper identifies a novel epithelial cell type, LND, in Crohn's disease that is associated with immune dysregulation and disease activity.

Nature Communications · Aug 22, 2024Peer-reviewedBioinformatics