Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination
Alerie Guzman de la Fuente, Marie Dittmer, Elise Jasmijn Heesbeen, Nira de la Vega Gallardo, Jessica A. White, Andrew Young, Tiree McColgan, Amy Dashwood, Katie Mayne, Sonia Cabeza‐Fernández, John Falconer, Francisco Javier Rodríguez‐Baena, Christopher E McMurran, Mohammed Inayatullah, Khalil S. Rawji, , Denise C. Fitzgerald
This study shows that ageing impairs regulatory T cells' ability to promote remyelination by reducing their capacity to drive oligodendrocyte differentiation and myelination.
bioRxiv · Jan 25, 2023 · PreprintNeuroscience