Author

Khalil S. Rawji

Wellcome/MRC Cambridge Stem Cell InstituteORCID 0000-0002-9687-8330Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Robin J.M. FrankliniD· 4 shared Chao ZhaoiD· 2 shared Juan F. Cubillos· 2 shared Penelope DimasiD· 2 shared Adrian ListoniD· 1 shared Alerie Guzman de la FuenteiD· 1 shared Amar SharmaiD· 1 shared Amber R. PhilpiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersNeuroscience

Robin J.M. FranklinORCID

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4 papers

Recent·Most cited

Extrinsic cues unlock cross-germ layer differentiation potential of CNS stem cells during regeneration

Civia Zi-Yu Chen, Yizhou Yu, Natalia A. Murphy, Juan F. Cubillos, Khalil S. Rawji, Chao Zhao, Myfanwy F. E. Hill, Peter Arthur‐Farraj, Robin J.M. Franklin, Björn Neumann

The paper identifies integrin and BMP signaling pathways that drive OPC-to-SC differentiation in CNS regeneration using single-cell genomics.

bioRxiv · Nov 24, 2025 · PreprintNeuroscience

Dysregulation of transcription networks regulating oligodendrogenesis in age-related decline in CNS remyelination

Penelope Dimas, Samuel Morabito, Khalil S. Rawji, Qing Wang, Fynn N. Krause, Juan F. Cubillos, Néjma Belaadi, Peggy Assinck, Zechuan Shi, Zhenkun Cao, Holger Heyn, Riki Kawaguchi, Daniel H. Geschwind, Vivek Swarup, Robin J.M. Franklin

The paper identifies age-related dysregulation of transcription networks in oligodendrocyte differentiation using single-nucleus RNA and ATAC sequencing in mice, with parallels in MS lesions.

bioRxiv · Nov 14, 2025 · PreprintNeuroscience

Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination

Amber R. Philp, Carolina R. Reyes, Josselyne B. Mansilla, Amar Sharma, Chao Zhao, Carlos Valenzuela‐Krugmann, Khalil S. Rawji, Ginez A. Gonzalez Martinez, Penelope Dimas, Bryan Hinrichsen, César Ulloa-Leal, Amie K. Waller, Diana M Bessa de Sousa, Maite A. Castro, Ludwig Aigner, , Francisco J. Rivera

This study shows platelets modulate OPC differentiation during remyelination, with transient exposure promoting and sustained exposure inhibiting differentiation in a mouse model of MS.

eLife · Nov 1, 2023Peer-reviewedNeuroscience

Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination

Alerie Guzman de la Fuente, Marie Dittmer, Elise Jasmijn Heesbeen, Nira de la Vega Gallardo, Jessica A. White, Andrew Young, Tiree McColgan, Amy Dashwood, Katie Mayne, Sonia Cabeza‐Fernández, John Falconer, Francisco Javier Rodríguez‐Baena, Christopher E McMurran, Mohammed Inayatullah, Khalil S. Rawji, , Denise C. Fitzgerald

This study shows that ageing impairs regulatory T cells' ability to promote remyelination by reducing their capacity to drive oligodendrocyte differentiation and myelination.

bioRxiv · Jan 25, 2023 · PreprintNeuroscience