Alerie Guzman de la Fuente

Inflammation-induced epigenetic memory restores oligodendrocyte progenitor cell regenerative capacity in the aged central nervous system

This study shows that inflammation-induced epigenetic memory in OPCs improves remyelination in aged mice by enhancing differentiation and reducing axonal damage.

PKC-dependent MYRF dysregulation links Aβ pathology to oligodendrocyte, myelin and cognitive alterations in Alzheimer's disease

This study identifies MYRF dysregulation as a mechanism linking Aβ pathology to oligodendrocyte and cognitive impairments in Alzheimer's disease, showing that PKC inhibition can restore myelin and cognition.

Regulatory T cells limit age-associated retinal inflammation and neurodegeneration

This study shows that regulatory T cells protect against age-related retinal inflammation and neurodegeneration by preventing retinal pigment epithelium dysmorphology and phagocyte accumulation in aged mice.

Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination

This study shows that ageing impairs regulatory T cells' ability to promote remyelination by reducing their capacity to drive oligodendrocyte differentiation and myelination.

The microbiota regulates inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination

This study shows that microbiota modulates inflammatory responses during CNS demyelination but has little effect on remyelination in mice.