Author

Amy Dashwood

Babraham InstituteORCID 0000-0002-4340-377XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Adrian ListoniD· 3 shared James DooleyiD· 3 shared Alerie Guzman de la FuenteiD· 2 shared Christopher E McMurraniD· 2 shared Denise C. FitzgeraldiD· 2 shared Rosana G. Peñalva· 2 shared Yvonne DombrowskiiD· 2 shared Alan W. StittiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

Adrian ListonORCID

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Author profile →

3 papers

Recent·Most cited

Directed disruption of IL2 aggregation sites produces designer biologics with enhanced specificity coupled to improved production capacity

A. J. Dashwood, Ntombizodwa Makuyana, Rob van der Kant, Arman Ghodsinia, Alvaro R. Hernandez, Stéphanie Liénart, Oliver T. Burton, James Dooley, Magda Mohamed Ali, Lubna Kouser, Francisco José Naranjo-Galindo, Matthew G. Holt, Frédéric Rousseau, Joost W. H. Schymkowitz, Adrian Liston

This paper designs IL2 muteins with enhanced Treg or CD8 T cell specificity and improved production by predicting mutations using SolubiS and testing their functional and structural properties.

Computational and Structural Biotechnology Journal · Jan 1, 2025Peer-reviewedImmunology

Regulatory T cells limit age-associated retinal inflammation and neurodegeneration

María Llorián‐Salvador, Alerie Guzman de la Fuente, Christopher E McMurran, Amy Dashwood, James Dooley, Adrian Liston, Rosana G. Peñalva, Yvonne Dombrowski, Alan W. Stitt, Denise C. Fitzgerald

This study shows that regulatory T cells protect against age-related retinal inflammation and neurodegeneration by preventing retinal pigment epithelium dysmorphology and phagocyte accumulation in aged mice.

Molecular Neurodegeneration · Apr 5, 2024Peer-reviewedNeuroscience

Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination

Alerie Guzman de la Fuente, Marie Dittmer, Elise Jasmijn Heesbeen, Nira de la Vega Gallardo, Jessica A. White, Andrew Young, Tiree McColgan, Amy Dashwood, Katie Mayne, Sonia Cabeza‐Fernández, John Falconer, Francisco Javier Rodríguez‐Baena, Christopher E McMurran, Mohammed Inayatullah, Khalil S. Rawji, , Denise C. Fitzgerald

This study shows that ageing impairs regulatory T cells' ability to promote remyelination by reducing their capacity to drive oligodendrocyte differentiation and myelination.

bioRxiv · Jan 25, 2023 · PreprintNeuroscience